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Assessment of toxicity of two nitroaromatic compounds in the freshwater fish

Hongyan SHEN, Jixi GAO, Jinsheng WANG

《环境科学与工程前沿（英文）》 2012年 第6卷 第4期   页码 518-523 doi: 10.1007/s11783-012-0427-6

摘要： This study was conducted to evaluate the toxicological response of -nitrotoluene and -nitroaniline to the key fish species, . A freshwater fish bioassay based on the 96 h was used to estimate the single and joint toxicity of the two chemicals. The toxicity of -nitrotoluene was greater than that of -nitroaniline based on 96 h values of 40.74 mg·L and 48.99 mg·L , respectively. Both compounds had moderate toxicity toward , and this toxicity increased with the exposure duration and concentration. Binary mixtures of the compounds were more toxic than the individual compounds at 96 h, and they acted upon partial addition. When the exposure time was longer, the toxicity increased for mixtures of compounds with the same concentration or toxicity. The results of this study suggest that exposure to a combination of these chemicals would result in a higher environmental risk in aquatic systems than exposure to either compound alone. Further research is needed to investigate the combined effects and sublethal toxicity of -nitrotoluene and -nitroaniline, since they are both still used in China.

关键词： joint toxicity     Cyprinus carpio     LC50     p-nitrotoluene     p-nitroaniline     toxic unit    

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Joint effects of Penta-BDE and heavy metals on

Baohua TANG, Lingyan ZHU, Qixing ZHOU

《环境科学与工程前沿（英文）》 2011年 第5卷 第1期   页码 99-110 doi: 10.1007/s11783-010-0260-8

摘要： The joint toxicity of Penta-BDE (Pe-BDE) and heavy metals including cadmium and copper on ( ) was evaluated on the basis of determining the 48 h survival, antioxidative enzyme responses, and lipid peroxidation. The response was classified as additive, greater than additive, or less than additive by comparing the measured “toxic units, TU” with one. Based on the survival of , less-than-additive interactions were found in most of mixtures treatments. This may be attributed to the different toxicity mechanism between Pe-BDE and metals. Cu and Cd played a greater role in toxicity than what Pe-BDE did. As for the superoxide dismutase (SOD) and catalase (CAT) activity, most response was less than additive. For the glutathione -transferases (GST) activity, most of the greater-than-additive responses were found in the Cu plus Pe-BDE treatments, but the additive responses occurred in Cd plus Pe-BDE treatments and binary metal treatments. For lipid peroxide levels, which were measured as malondialdehyde (MDA) levels, less-than-additive response occurred in the 50% Cd plus 50% Cu and ternary mixture treatments. Results suggested that Pe-BDE, Cd, and Cu could induce different patterns of antioxidant enzyme responses, such as antioxidant/prooxidant responses, depending on their capability to produce reactive oxygen species and antioxidant enzymes to detoxify them.

关键词： polybrominated diphenyl ethers (PBDEs)     heavy metal     mixture toxicity     toxic units (TUs)     antioxidant enzyme     lipid peroxidation    

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Analytical algorithms of compressive bending capacity of bolted circumferential joint in metro shield

《结构与土木工程前沿（英文）》   页码 901-914 doi: 10.1007/s11709-023-0915-8

摘要： The integrity and bearing capacity of segment joints in shield tunnels are associated closely with the mechanical properties of the joints. This study focuses on the mechanical characteristics and mechanism of a bolted circumferential joint during the entire bearing process. Simplified analytical algorithms for four stress stages are established to describe the bearing behaviors of the joint under a compressive bending load. A height adjustment coefficient, α, for the outer concrete compression zone is introduced into a simplified analytical model. Factors affecting α are determined, and the degree of influence of these factors is investigated via orthogonal numerical simulations. The numerical results show that α can be specified as approximately 0.2 for most metro shield tunnels in China. Subsequently, a case study is performed to verify the rationality of the simplified theoretical analysis for the segment joint via numerical simulations and experiments. Using the proposed simplified analytical algorithms, a parametric investigation is conducted to discuss the factors affecting the ultimate compressive bending capacity of the joint. The method for optimizing the joint flexural stiffness is clarified. The results of this study can provide a theoretical basis for optimizing the design and prediciting the damage of bolted segment joints in shield tunnels.

关键词： shield tunnel     segment joint     joint structural model     failure mechanism    

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Reproductive toxicity study with a novel deoxyguanosine analogue (Metacavir) in pregnant SD rats

null

《医学前沿（英文）》 2015年 第9卷 第1期   页码 82-89 doi: 10.1007/s11684-015-0376-0

摘要：

Our preliminary studies demonstrated that Metacavir has potential to become a new anti-HBV agent. The main targets of the toxic effects of Metacavir, in rhesus monkeys, were gastrointestinal tracts, liver, blood, and kidneys, which were not related to mitochondrial effects. In this study, the maternal toxicity, embryo-fetal developmental toxicity and teratogenicity were studied in pregnant Sprague-Dawley rats after intragastric administration of Metacavir (200, 100, 50, 0 mg/kg body weight) during the first 6–15 days of pregnancy. Slower weight gain was observed in 5 out of 21 rats subjected to a 200 mg/kg dose, as well as 2 out of 20 subjected to a 100 mg/kg dose. Compared with the solvent control group, the calibration weight gain in the 200 mg/kg and 100 mg/kg dosage groups respectively, during first 6–20 pregnant days were significantly different (P<0.01, P<0.05). Significant dose related adverse effects to other reproductive parameters were not seen in F0 and F1, but the number of stillbirths in high dose group showed notably difference compared with the control group (P<0.05), while the litter incidence showed no difference. No Metacavir-associated pathological changes were observed. The present research indicated that at a dose of 200 mg/(kg·d) (i.e., 40 times the effective dose in rats), Metacavir shows some maternal toxicity to SD rats. The embryotoxicity in the 200 mg/kg group encompass decreased fetal body weight, and higher fetal mortality rates, compared with the control group. However, the litter incidence showed no statistical difference. All the treated rats displayed normal bone development, no teratogenicity and without adverse effects on fetal development, thus indicating that below a dose of 200 mg/(kg·d) there is no teratogenic side effects.

关键词： deoxyguanosine analogue     Metacavir     pregnancy     maternal toxicity     embryo toxicity     teratogenicity    

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Interaction and combined toxicity of microplastics and per- and polyfluoroalkyl substances in aquatic

《环境科学与工程前沿（英文）》 2022年 第16卷 第10期 doi: 10.1007/s11783-022-1571-2

摘要：

● Adsorption of PFASs on MPs and its mechanisms are critically reviewed.

关键词： Microplastics     Per- and Polyfluoroalkyl substances     Adsorption     Transport     Transformation    

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Product identification and toxicity change during oxidation of methotrexate by ferrate and permanganate

《环境科学与工程前沿（英文）》 2022年 第16卷 第7期 doi: 10.1007/s11783-021-1501-8

摘要：

• Oxidation of methotrexate by high-valent metal-oxo species was first explored.

关键词： Anticancer drugs     High-valent metal-oxo species     Oxidation kinetics     Reaction mechanisms     Multi-endpoint toxicity    

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Evaluation of soil microbial toxicity of waste foundry sand for soil-related reuse

Haifeng ZHANG, Lu SU, Xiangyu LI, Jiane ZUO, Guangli LIU, Yujue WANG

《环境科学与工程前沿（英文）》 2014年 第8卷 第1期   页码 89-98 doi: 10.1007/s11783-013-0591-3

摘要： The relationship between the chemical contaminants and soil microbial toxicity of waste foundry sand (WFS) was investigated. Five different types of WFS from typical ferrous, aluminum, and steel foundries in China were examined for total metals, leachable metals, and organic contaminants. The soil microbial toxicity of each WFS was evaluated by measuring the dehydrogenase activity (DHA) of a blended soil and WFS mixture and then comparing it to that of unblended soil. The results show that the five WFSs had very different compositions of metal and organic contaminants and thus exhibited very different levels of soil microbial inhibition when blended with soil. For a given WFS blended with soil in the range of 10 wt.%–50 wt.% WFS, the DHA decreased almost linearly with increased blending ratio. Furthermore, for a given blending ratio, the WFSs with higher concentrations of metal and organic contaminants exhibited greater microbial toxicity. Correlation analysis shows that the relationship between ecotoxicity and metal and organic contaminants of WFSs can be described by an empirical logarithmic linear model. This model may be used to control WFS blending ratios in soil-related applications based on chemical analysis results to prevent significant inhibition of soil microbial activity.

关键词： waste foundry sand     toxicity     bioassay     soil microbial activity     waste reuse    

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Finite element analysis on the seismic behavior of side joint of Prefabricated Cage System in prefabricated

Yunlin LIU, Shitao ZHU

《结构与土木工程前沿（英文）》 2019年 第13卷 第5期   页码 1095-1104 doi: 10.1007/s11709-019-0538-2

摘要： The Prefabricated Cage System (PCS) has the advantages of high bearing capacity and good ductility. Meanwhile, it is convenient for factory production and it is beneficial to the cost savings, construction period shortening. Side joint is the weak region of PCS concrete frame and has great influence on seismic behavior of the whole structure. Thus systematically study on the seismic behavior of PCS concrete side joint is necessary. This paper presents a finite element study on behavior of the side joint under seismic loading. In the finite element model, PCS concrete and the reinforced concrete (RC) is modeled by the solid element and fiber-beam element, respectively. The numerical results is compared with the experimental results and it is found that the results of model based on fiber-beam element is in better agreement with the experimental results than solid element model. In addition, the overall seismic behavior of the side joints in PCS concrete is better than that of the RC with the same strength.

关键词： PCS concrete side joint     numerical simulation     fiber-beam element joint model     solid element joint model     seismic behavior    

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ROUTE DEVELOPMENT, ANTIVIRAL STUDIES, FIELD EVALUATION AND TOXICITY OF AN ANTIVIRAL PLANT PROTECTANT

《农业科学与工程前沿（英文）》 2022年 第9卷 第1期 doi: 10.15302/J-FASE- 2021390

摘要：

It has previously been shown that tryptophan, the biosynthesis precursor of Peganum harmala alkaloids, and its derivatives have anti-TMV activity both in vitro and in vivo. Further exploration of this led to the identification of NK0238 as a highly effective agent for the prevention and control of diseases caused by plant viruses, but the existing routes are unsuitable for its large-scale synthesis. This study optimized a route for two-step synthesis of this virucide candidate via reaction of l-tryptophan with triphosgene to produce l-tryptophan-N-carboxylic anhydride, which then reacts with n-octylamine to give NK0238 at up to 94% yield and nearly 97% HPLC purity. In addition, the route was used for the preparation of NK0238 on a>40 g scale permitting further assessment of its antivirus activity in the greenhouse and field experiments, and toxicity tests. NK0238 exhibited useful antiviral activities against a variety of viruses both in greenhouse and field experiments. The toxicity tests showed that NK0238 was not acutely toxic to birds, fish, honey bees and silkworms. The optimized route provides a solid foundation for its large-scale synthesis and subsequent efficacy and toxicity studies, its excellent activity and safety make NK0238 a promising drug candidate for further development.

 

关键词： antiviral plant protectant / antiviral in the greenhouse / field evaluation / l-trp-NCA / synthesis optimization / toxicity tests    

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Understanding the role of nano-TiO on the toxicity of Pb on through modeling–Is it additive or synergistic

《环境科学与工程前沿（英文）》 2022年 第16卷 第5期 doi: 10.1007/s11783-021-1493-4

摘要：

• A two-compartment model is able to quantify the effect of nano-TiO2 on Pb toxicity.

关键词： Algae     C. dubia     Lead     Nano-TiO2     Synergistic toxicity     Two-compartment toxicokinetic-toxicodynamic model    

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Toxicity models of metal mixtures established on the basis of “additivity” and “interactions”

Yang Liu,Martina G. Vijver,Bo Pan,Willie J. G. M. Peijnenburg

《环境科学与工程前沿（英文）》 2017年 第11卷 第2期 doi: 10.1007/s11783-017-0916-8

摘要： · No preference is set between CA and IA models to assess toxicity of metal mixtures. · Increased model complexity does not, by itself, lead to improved performance. · Not all significant deviations have biological meaning due to poor reproducibility. · Interactions are suggested to incorporate when they are significant and repeated. Observed effects of metal mixtures on animals and plants often differ from the estimates, which are commonly calculated by adding up the biological responses of individual metals. This difference from additivity is commonly referred to as being a consequence of specific interactions between metals. The science of how to quantify metal interactions and whether to include them in risk assessment models is in its infancy. This review summarizes the existing predictive tools for evaluating the combined toxicity of metals present in mixtures and indicates the advantages and disadvantages of each method. We intend to provide eco-toxicologists with background information on how to make good use of the tools and how to advance the methods for assessing toxicity of metal mixtures. It is concluded that statistically significant deviations from additivity are not necessarily biologically relevant. Incorporation of interactions between metals in a model does not on forehand mean that the model is more accurate than a model developed based on additivity only. It is recommended to first use a relatively simple method for effect prediction of uninvestigated metal mixtures. To improve the reliability of toxicity modeling for metal mixtures, further efforts should focus on balancing the relationship between the significance of statistics and the biological meaning, and unraveling the toxicity mechanisms of metals and their mixtures.

关键词： Metal     Mixtures     Toxicity     Additivity     Modeling     Interactions    

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Leaching toxicity characteristics of municipal solid waste incineration bottom ash

Khamphe PHOUNGTHONG,Yi XIA,Hua ZHANG,Liming SHAO,Pinjing HE

《环境科学与工程前沿（英文）》 2016年 第10卷 第2期   页码 399-411 doi: 10.1007/s11783-015-0819-5

摘要： The continuously increasing production of municipal solid waste incineration bottom ash (MSWIBA) has promoted its utilization as construction material and raised environmental concern. The physico-chemical properties and leaching behavior of MSWIBA were studied, and ecotoxicological testing using a luminescent bacterium bioassay was performed to assess the ecological pollution risks associated with its leached constituents. The MSWIBA was leached by two types of leachants, H SO /HNO and HAc solution, at different liquid to solid ratios and contact times. The concentrations of heavy metals and anions in the leachates were analyzed. Multivariate statistical analyses, including principle component analysis, Pearson's correlation analysis and hierarchical cluster analysis, were used to evaluate the contributions of the constituents to the toxicity ( ) of the MSWIBA leachate. The statistical analyses of the ecotoxicological results showed that the Ba, Cr, Cu, Pb, F and total organic carbon (TOC) concentrations were closely correlated with the value, and these substances were the main contributors to the ecotoxicity of the MSWIBA leachate. In addition, the cluster of these variables indicated similar leaching behaviors. Overall, the research demonstrated that the ecotoxicological risks resulting from MSWIBA leaching could be assessed before its utilization, which provides crucial information for the adaptation of MSWIBA as alternative materials.

关键词： Municipal solid waste incineration     bottom ash     alternative material     leaching tests     toxicity     Vibrio qinghaiensis (Q67)    

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Toxicity-oriented water quality engineering

Shengkun Dong, Chenyue Yin, Xiaohong Chen

《环境科学与工程前沿（英文）》 2020年 第14卷 第5期 doi: 10.1007/s11783-020-1259-4

摘要： • Toxicity-oriented water quality monitoring was proposed. • Toxicity-oriented water quality engineering control was proposed. • Future issues to the proposition were discussed. The fundamental goal of water quality engineering is to ensure water safety to humans and the environment. Traditional water quality engineering consists of monitoring, evaluation, and control of key water quality parameters. This approach provides some vital insights into water quality, however, most of these parameters do not account for pollutant mixtures – a reality that terminal water users face, nor do most of these parameters have a direct connection with the human health safety of waters. This puts the real health-specific effects of targeted water pollutant monitoring and engineering control in question. To focus our attention to one of the original goals of water quality engineering – human health and environmental protection, we advocate here the toxicity-oriented water quality monitoring and control. This article presents some of our efforts toward such goal. Specifically, complementary to traditional water quality parameters, we evaluated the water toxicity using high sensitivity toxicological endpoints, and subsequently investigated the performance of some of the water treatment strategies in modulating the water toxicity. Moreover, we implemented the toxicity concept into existing water treatment design theory to facilitate toxicity-oriented water quality control designs. Suggestions for the next steps are also discussed. We hope our work will intrigue water quality scientists and engineers to improve and embrace the mixture water pollutant and toxicological evaluation and engineering control.

关键词： Water     Wastewater     Mixture     Toxicity     Monitor     Control    

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Predictive models on photolysis and photoinduced toxicity of persistent organic chemicals

Qing ZHANG

《环境科学与工程前沿（英文）》 2013年 第7卷 第6期   页码 803-814 doi: 10.1007/s11783-013-0547-7

摘要： Photodegradation is a major abiotic transformation pathway of toxic chemicals in the environment, which in some cases might lead to photoinduced toxicities. The data on photodegradation kinetics and photoinduced toxicities of organic chemicals are essential for their risk assessment. However, the relevant data are only available for a limited number of chemicals, due to the difficulty and high cost of experimental determination. Quantitative structure-activity relationship (QSAR) models that relate photodegradation kinetics or photoinduced toxicity of organic chemicals with their physicochemical properties or molecular structural descriptors may enable simple and fast estimation of their photochemical behaviors. This paper reviews the QSAR models on photodegradation quantum yields and rate constants for toxic organic chemicals in different media including liquid phase, gaseous phase, surfaces of plant leaves, and QSAR models on photoinduced toxicity of organic chemicals to plants, bacteria, and aquatic invertebrates. Further prospects for QSAR model development on photodegradation kinetics and photoinduced toxicity of refractory organic chemicals are proposed.

关键词： quantitative structure-activity relationship (QSAR) models     photodegradation     persistent organic pollutants     environmental media     mechanisms    

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Dynamic characteristics of a magnetorheological pin joint for civil structures

Yancheng LI,Jianchun LI

《机械工程前沿（英文）》 2014年 第9卷 第1期   页码 15-33 doi: 10.1007/s11465-014-0283-0

摘要：

Magnetorheological (MR) pin joint is a novel device in which its joint moment resistance can be controlled in real-time by altering the applied magnetic field. The smart pin joint is intended to be used as a controllable connector between the columns and beams of a civil structure to instantaneously shift the structural natural frequencies in order to avoid resonance and therefore to reduce unwanted vibrations and hence prevent structural damage. As an intrinsically nonlinear device, modelling of this MR fluid based device is a challenging task and makes the design of a suitable control algorithm a cumbersome situation. Aimed at its application in civil structure, the main purpose of this paper is to test and characterise the hysteretic behaviour of MR pin joint. A test scheme is designed to obtain the dynamic performance of MR pin joint in the dominant earthquake frequency range. Some unique phenomena different from those of MR damper are observed through the experimental testing. A computationally-efficient model is proposed by introducing a hyperbolic element to accurately reproduce its dynamic behaviour and to further facilitate the design of a suitable control algorithm. Comprehensive investigations on the model accuracy and dependences of the proposed model on loading condition (frequency and amplitude) and input current level are reported in the last section of this paper.

关键词： Magnetorheological pin joint     hyperbolic hysteresis model experimental testing frequency dependence    

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标题 作者 时间 类型 操作

Assessment of toxicity of two nitroaromatic compounds in the freshwater fish

Hongyan SHEN, Jixi GAO, Jinsheng WANG

期刊论文

Joint effects of Penta-BDE and heavy metals on

Baohua TANG, Lingyan ZHU, Qixing ZHOU

期刊论文

Analytical algorithms of compressive bending capacity of bolted circumferential joint in metro shield

期刊论文

Reproductive toxicity study with a novel deoxyguanosine analogue (Metacavir) in pregnant SD rats

null

期刊论文

Interaction and combined toxicity of microplastics and per- and polyfluoroalkyl substances in aquatic

期刊论文

Product identification and toxicity change during oxidation of methotrexate by ferrate and permanganate

期刊论文

Evaluation of soil microbial toxicity of waste foundry sand for soil-related reuse

Haifeng ZHANG, Lu SU, Xiangyu LI, Jiane ZUO, Guangli LIU, Yujue WANG

期刊论文

Finite element analysis on the seismic behavior of side joint of Prefabricated Cage System in prefabricated

Yunlin LIU, Shitao ZHU

期刊论文

ROUTE DEVELOPMENT, ANTIVIRAL STUDIES, FIELD EVALUATION AND TOXICITY OF AN ANTIVIRAL PLANT PROTECTANT

期刊论文

Understanding the role of nano-TiO on the toxicity of Pb on through modeling–Is it additive or synergistic

期刊论文

Toxicity models of metal mixtures established on the basis of “additivity” and “interactions”

Yang Liu,Martina G. Vijver,Bo Pan,Willie J. G. M. Peijnenburg

期刊论文

Leaching toxicity characteristics of municipal solid waste incineration bottom ash

Khamphe PHOUNGTHONG,Yi XIA,Hua ZHANG,Liming SHAO,Pinjing HE

期刊论文

Toxicity-oriented water quality engineering

Shengkun Dong, Chenyue Yin, Xiaohong Chen

期刊论文

Predictive models on photolysis and photoinduced toxicity of persistent organic chemicals

Qing ZHANG

期刊论文

Dynamic characteristics of a magnetorheological pin joint for civil structures

Yancheng LI,Jianchun LI

期刊论文